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People with OAB often limit travel, social and even work activities to avoid potentially embarrassing episodes that can occur with this condition.

It is important that we continue to advance technology to bring new options to people with overactive bladder to help them manage this condition," said Nancy Muller, executive director, National Association for Continence. In total, Enablex has been studied in 98 clinical trials involving more than 10, people. In clinical trials, the most frequently reported adverse events associated with Enablex were dry mouth and constipation, however patient discontinuation rates due to these events were low.

The majority of adverse events in Enablex treated subjects were mild or moderate and mostly occurred during the first two weeks of treatment. As with other OAB medications, Enablex is contraindicated in patients with urinary retention, gastric retention or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions. Enablex is also contraindicated in patients with known hypersensitivity to the drug or its ingredients.

This release contains certain forward-looking statements relating to Novartis Pharmaceuticals Corporation's business, which can be identified by the use of forward-looking terminology, such as "is expected," "will be," and "have the potential to" or similar expressions, or by express or implied discussions regarding potential future sales of Enablex. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results with Enablex to be materially different from any future results, performance, or achievements expressed or implied by such statements.

There can be no guarantee that Enablex will reach any particular level of sales. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

In , the Group's businesses achieved sales of USD The Group invested approximately USD 3. Headquartered in Basel, Switzerland, Novartis Group companies employ about 81, people and operate in over countries around the world. This move will certainly help to reduce the malaria burden for millions of people, especially children, and prevent malaria deaths and severe and complicated malaria episodes. Novartis has also concluded agreements for supply of Final Coartem production in is highly dependent on the timely delivery of sufficient quantities of the key raw materials artemisinin and artemether by Chinese suppliers who currently dominate the world market.

Based on the escalation of WHO estimates of the number of treatments needed, we have invested in new production capacity and supply agreements with our Chinese partners," said Dr. To help ensure that the medicine is broadly accessible to needy patients, we make Coartem available at cost to the WHO for supply to the public sector of malaria endemic developing countries.

Up to now we have been subsidizing Coartem and do not anticipate ever making a profit from future sales. Artemether-lumefantrine is on the WHO's Essential Medicines list and is the only ACT pre-qualified by the WHO for use in countries experiencing high levels of resistance to conventional anti-malaria drugs. Jack C. Artemisinin, the active ingredient in Coartem and all other ACTS, is a plant derived raw material and crops of Artemisia annua must be planted one growing season ahead of harvesting and extraction for use in production. The cultivation of Artemisia annua requires a minimum of six months.


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The supply chain for manufacturing ACTs is particularly complex and time-consuming, adding an additional two to five months to production timelines depending on product formulation. We have seen remarkable results with this new class of drugs. Production capacity has been ramped up as usage has risen exponentially, but we need to ensure sufficient agricultural production of artemisinin to sustain this progress.

Malaria morbidity and mortality rates are rising in developing countries, largely due to the emergence of drug resistant parasites rendering traditional antimalarial drugs, such as chloroquine, sulfadoxine-pyrimethamine SP ineffective. In addition to the devastating toll malaria takes on human life in terms of morbidity and mortality, the disease also has substantial negative impacts on the economic development of nations in which the disease is endemic.

It is indicated for the treatment of falciparum malaria, the most dangerous form of malaria. Coartem is the only pre-qualified, fixed-dose ACT combining artemether, an artemisinin derivative, and lumefantrine. Artemisinin is a compound derived from the sweet wormwood plant and has been used for centuries in traditional Chinese medicine to treat fever. An artemisinin-based combination therapy is a combination of two or more drugs one of which is an artemisinin derivative that have different modes of action and different targets.

Osteoarthritic Joint Pain

Studies have shown that using two or more drugs in combination has the potential to delay the development of resistance in areas of low transmission. Artemisinin-based combination therapies in particular have been found to be highly effective in treating malaria and their potential to delay resistance in areas of intense transmission is under investigation.

Coartem was co-developed by Novartis in collaboration with Chinese partners who also supply the active ingredients artemether and lumefantrine and is produced in China by Novartis. Coartem has been extensively studied in multi-center clinical trials involving more than 3, patients. This release contains certain forward-looking statements that can be identified by the use of forward-looking terminology, such as "will occur", "help alleviate", "continue", "remain committed", "will benefit", "will evaluate" or similar expressions, or by express or implied discussions regarding Novartis' ability to satisfy the WHO's requirements for Coartem production in the future.

Such forward looking statements reflect the current views of the Company or WHO, as the case may be, regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause the actual results with Coartem to be materially different from any future results, performance, or achievements expressed or implied by such statements.


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There can be no guarantee that Novartis will be able to achieve any particular level of Coartem production in the future. Headquartered in Basel, Switzerland, Novartis Group companies employ about 80 people and operate in over countries around the world. Emselex, a new once-daily M3 selective receptor antagonist M3 SRA recently received marketing approval from the European Commission in 25 European member states as well as Norway and Iceland for the treatment of overactive bladder OAB. Under the terms of the collaboration, Novartis remains the owner of the EU marketing authorization for darifenacin, while Bayer Vital gains exclusive commercialization rights for Emselex in Germany.

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Emselex is a once-daily M3 selective receptor antagonist M3 SRA oral treatment that works by selectively inhibiting the M3 receptor, the primary mediator of detrusor contraction, while sparing the M1 and M2 receptors that are located in various body organs, including the brain and heart.

To date, 98 clinical trials with Emselex have been completed involving more than 10, subjects and patients, of whom 7, were treated with darifenacin. Across a range of pivotal endpoints, Emselex has been shown to significantly improve all other key symptoms of OAB, including the number of times patients had to visit the bathroom each day, bladder capacity, frequency of urgency, severity of urgency and the number of incontinence episodes leading to a change in clothing or pads. Emselex 7.

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Novartis is able to market Emselex throughout these countries. This product is known as Enablex in the US. Symptoms of overactive bladder include urinary urgency a sudden and compelling desire to pass urine, which is difficult to defer with, or without, urge incontinence involuntary leakage accompanied by urgency , usually with urinary frequency voiding the bladder too often and nocturia waking at night one or more times to void the bladder. This release contains certain forward-looking statements that can be identified by the use of forward-looking terminology, such as "will reach", or similar expressions, or by express or implied discussions regarding potential additional marketing approvals or future sales of Emselex.

Such forward looking statements reflect the current views of the Company regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause the actual results with Emselex to be materially different from any future results, performance, or achievements expressed or implied by such statements.

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There can be no guarantee that Emselex will receive any additional marketing approvals in any other countries, or that it will reach any particular sales levels. Patients taking Exelon showed statistically significant benefits on a range of symptoms, such as loss of memory, concentration and behavioral problems.

They were also able to cope better with everyday activities like watching TV or talking about current events. Rivastigmine is a therapy that has been shown to improve symptoms frequently seen in patients suffering from dementia associated with PD and thus offers hope to provide a better quality of life," Dr.

Emre said. Dementia is one of the complications most feared by PD patients.

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Sometimes institutional care is the only option and this places a significant economic burden on the family and the state. Results like this give new hope to families caring for a loved one with dementia and may improve the quality of life of the whole family,". Over a week study period, patients were randomly assigned to a daily dose of mg Exelon or placebo.

Patients who were treated with Exelon showed a mean 2. The side effects associated with Exelon during this study were mild to moderate in nature and included nausea and vomiting. Importantly, motor scale assessments showed that Parkinsonian symptoms were not worsened overall relative to baseline or placebo.


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Mild to moderate tremor was reported in Exelon-treated patients, but this rarely resulted in withdrawal from the study. Exelon is a treatment for mild to moderate Alzheimer's disease. It belongs to a class of drugs known as cholinesterase inhibitors ChEI's which increase neurotransmitter activity in the brain. It was approved for the treatment of Alzheimer's disease in and is currently used in over 70 countries.

This may offer additional benefits over treatments which inhibit AChE alone. Exelon can maintain both memory and thinking, help with behavioral problems and affect how patients cope with the activities of daily living. It may help them communicate better, interact socially, participate in hobbies and eat and dress independently. Parkinson's disease PD is a chronic and progressive neurological condition estimated to affect 6. This deficit contributes to the cognitive and behavioral problems observed in these patients. Patients with dementia associated with Parkinson's disease typically have problems with memory, concentration, activities of daily living, as well as depression, anxiety, apathy and hallucinations.

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Alzheimer's disease AD is a progressive, degenerative disease that alters the brain, causing impaired memory, thinking and behavior. This release contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward-looking terminology such as "provides significant benefits", "could", "offers hope to provide", "may improve", "might represent", "may offer", "may help", "is committed to addressing", or similar expressions, or by express or implied discussions regarding potential new indications for Exelon, or regarding potential future revenue from Exelon.

Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results with Exelon to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that Exelon will be approved for any additional indications in any market or regarding potential future revenue from Exelon.

Novartis continues to be active in the research and development of new compounds, is committed to addressing unmet medical needs and to supporting patients and their families affected by these disorders. Headquartered in Basel, Switzerland, Novartis Group companies employ approximately 80, people and operate in over countries around the world. Novartis investigational drug ICL demonstrates positive results in treating chronic iron overload, a potentially life-threatening condition.

Data from three studies were presented at the annual meeting of the American Society of Hematology in San Diego, California.